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BBC News with Fiona McDonald.

A huge truck bomb was devastated at the Marriott Hotel in the center of the Pakistani capital, Islamabad, killing at least 40 people and injured about 250. The explosion blew out the lorry, floors of the building, covering a deep crater in front of it and sending people fleeing from restaurants at the back where they were breaking the Ramadan fast. The explosion came hours after Pakistani new President Asif Ali Zardari addressed parliament for the first time and demanded an end to Islamist militancy. The BBC’s Shoaib Hasan reports.

Mr. Zardari condemned what he said was horrific and // Pakistani citizens. He said his heart was tears of blood for those killed. Calling that attack part of epidemic, Mr. Zardari emphasized Pakistanis to committee to eliminate it come what mean. A suicide bomb struck the Marriott Hotel in capital Islamabad within hours of his inaugurated address to parliament earlier on Saturday. The subsequent explosion was the most devastating in the capital’s history. Emergency workers had great difficulties with moving the dead and injured from the scene. Rescue workers say many people could still be trapped under the debris.

President Bush says the United States will help Pakistan bringing the perpetrators of the Islamabad bombing to justice. No group has yet said carried out the attack. But Mr. Bush said now was the time to refocus efforts on defeating al-Qaeda.

A spokesman to the South African President Thabo Mbeki has said the president will resign following demands from his own party, the African National Congress. ANC leaders made the call of allegations at Mr. Mbeki interfered in a corruption case against his rival, the party leader Jacob Zuma. The President of the opposition party, the Democratic Alliance, Helen Zille told the BBC that Mr. Mbeki’s r esignation has been orchestrated to protect Mr Zuma from corruption allegations.

The ANC has made its own internal problems a crisis for the country. This is exactly the political solution that Jacob Zuma has always wanted. It's about revenge; it's about seeking political scores. And it is quite predictable that Jacob Zuma and his allies are going to use their new position to ensure that he does not have to face the 783 allegations of corruption against him in court.

The Large Hadron Collider where scientists were trying to simulate the conditions that existed just after the Big Bang when the Universe came into existence will have to be shut down for at least two months. Dr. Dev Davnes is leading one of the experiments being conducted.

All of these are so enormously disappointed where they are ready to analyze the first data. After the success of the switch on a week and half ago, everything was going so well. You know, this is probably the most complicated machine in the world. So these things happened.

World News from the BBC.

The 700-billion-dollar government rescue plan for financial institutions in the United States could be ready for President Bush to sign by Friday. The Chairman of Congress Joint Economic Committee Senate Charles Schumer said legislators were working with the US Treasury Secretary Henry Paulson on a number of options, including a supervisory authority. From Washington, Jonathan Beale reports.

The rescue package now being discussed would man to the biggest bailout by the US government since the great depression of the 1920s. The cost of it has already rocketed from 500 to 700 billion dollars. The nets on top the hundreds of billions of taxpayers’ money already used to save the mortgage giants, Fannie Mae and Freddie Mac, the insurer AIG, and Bear Stearns Bank.

The military government in Mauritania has declared three days of mourning following the discovery of decapitated bodies of 12 soldiers. The bodies were dumped in the desert outside northern town where the soldiers were captured on Monday. The authorities have called for international support in the fight against terrorism, describing it as a very grieve threat to the stability of the region. A group calling itself al-Qaeda’s North Africa wing has said it had abducted the soldiers during an ambush on an army patrol.

A Spanish plane repatriating more than 100 illegal migrants to Gambia has been forced to return to Spain after the Gambian authorities refused to let them disembark. Gambian officials said Spain had not given them enough time to prepare to receive the deportees. Spanish officials expressed surprise, said Gambia had approved the repatriation.

The authorities in Southern Croatia vowed the partially evacuation of the town of Makarska which is threatened by a forest fire. Winds with gust of up to 100 km/hour are driving the blaze towards the coast resort. Planes and helicopters have been brought in to help the 300 firefighters tackling the fire.

BBC news.